叶丽虹 _生活百科

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叶丽虹【叶丽虹】叶丽虹，女。1997年毕业于日本群马大学医学部分子药理专业，获医学博士学位（M.D., Ph.D.）。现任南开大学生命科学学院教授，博士生导师，南开大学及天津市特聘教授，蛋白质生化研究室主任。中国抗癌协会肿瘤标誌物专业委员会委员。国家863计画、自然科学基金和教育部留学回国基金等项目评审专家。美国《The Open Translational Medicine Journal》杂誌编委，《生物化学与生物物理学进展》和《细胞生物学杂誌》等论文审稿人。日本群马大学客座研究员。大连医科大学和承德医学院客座教授。
基本介绍中文名：叶丽虹
国籍：中国
职业：教师
毕业院校：日本群马大学
主要成就：多次获得优秀论文奖
性别：女
个人经历1983年毕业于中国医科大学医疗系本科， 1989获得医学硕士学位后任大连医科大学讲师， 1992年赴日本群马大学攻读博士学位（文部省奖学金资助）， 1997获医学博士学位。在日本学术振兴会（JSPS）奖学金资助下做博士后两年，之后就职于日本理化学研究所任研究员。2000年底辞职，以“引进人才”到南开大学任教授，新组建蛋白质生化研究室。回国后先后主持国家自然科学基金5项（在研2项）、天津市科技发展计画重点项目（3项）和教育部基金（2项）。参加973项目1项(骨干)和国家自然科学基金2项。培养博士后1人，培养博士生7人，硕士生17人。已获得国家发明专利2项，申请国家发明专利11项。在Genbank登入新基因2个。2005年在天津市“巾帼发明家”活动中获“优秀髮明者”称号,2007年荣获天津市智慧财产权系统“十大女杰”称号， 2008年在天津市“巾帼发明家”活动中获“巾帼发明家创新奖”称号。承担博士生《分子生物学前沿讲座》和硕士生《高级生化II》的必修课程，担任本科生《生命科学前沿讲座》。迄今在国际权威杂誌PNAS和JBC等杂誌上发表论文120篇，其中SCI论文40篇，总影响因子大于100 ，他人引用总计200余次。应美国Nova科学出版社邀请，编写并出版B型肝炎病毒专着2部。多次应邀在国内外学术会议上作大会发言，并。论文成果SCI论文:1.Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH*, Zhang XD. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving 5-LOX, NF-κB, OPN and Capn4. PLoS One, 2012;7(2):e31458. (IF=4.3)2.Zhang W, Kong G, Zhang J, Wang T, Ye LH*, Zhang XD. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2): e31450. (IF=4.3)3.Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD, Ye LH*. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack. FEBS Letters, doi:10.1016/j.febslet.2012.01. 0392012, Jan 27. [Epub ahead of print] (IF=2.7)4.Zhao Y, Wang W, Wang Q, Zhang XD, Ye LH*. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells. Biochem Biophys Res Commun. 2012; 418(4):647-651 (IF=2.7)5.Wang Q ， Zhang T ， Ye LH ， Wang WH ， Zhang XD. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China. Cancer Epidemiol. 2011 Dec 16. [Epub ahead of print] (IF=1.4)6.Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*.MicroRNA-520e Suppresses Growth of Hepatoma Cells by Targeting the NF-κB-inducing Kinase (NIK). Oncogene, 2011 Nov 21. doi: 10.1038/onc.2011.523. [Epub ahead of print](IF=7.4)7.Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin. 2011;32:1173-1180 (IF=1.9)8.Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang X. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. PLoS One. 2011;6(5):e19518.(IF=4.3)9.Shan C, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Zhang Z, Ye LH*, Zhang XD. HBx activates CD59 through indirectly binding to the region of the CD59 promoter and down-regulating Let-7i. Carcinogenesis. 2011;32 (8):1190-7 (IF=5.4)10.张烜，叶丽虹* ，张晓东.骨桥蛋白通过NF-kB上调钙蛋白酶小亚基1促进肝癌细胞迁移。生物化学与生物物理进展.2010；37(5): 534-539. 11.张学智, 山长亮, 叶丽虹*,张晓东. RNA干扰在抗B肝治疗中的套用及其研究进展. 生物化学与生物物理进展. 2008;35(6):631-63612.王凤泽，沙丽，乔玲，吴莲英，张晓东，叶丽虹*.B肝病毒X蛋白结合蛋白（HBXIP）增强肝癌细胞NF-кB转录活性的实验研究. 生物化学与生物物理进展2007;34(11):1-513.乔玲, 徐治立, 谭旭, 叶丽虹*, 张晓东.间充质干细胞释放Dkk-1抑制乳腺癌细胞Wnt/β-catenin途径的实验研究. 生物化学与生物物理进展2007;34(7): 702-70814.叶丽虹,尤嘉琮,张晓东,蔡娜,乔玲,王长晔.刘毅吴晶辉吴莲英王洪辉套用基因表达谱晶片从不同转移能力的乳腺癌细胞中筛选转移相关基因. 生物化学与生物物理进展2005;32(5): 421-428着作：1.《Progress in Hepatitis B Research》 (ISBN: 1-60021-687-0) Editors: Dorothy V. Denyer. Nova publishers of America. Published in Dec. 2007.Xiaodong Zhang, Weiying Zhang and Lihong Ye wrote the Chapter V - Hepatitis B Virus Research Focus; pp. 113-2012.《Hepatitis B Virus Research Focus》(ISBN: 978-1-60456-299-6) Writers: Xiaodong Zhang, Weiying Zhang, Lihong Ye. Nova publishers of America. Published in Nov 2008.主要学术论文::张晓东;东楠; 张航; 尤嘉琮; 王洪辉; 叶丽虹. Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cel. JOURNAL OF LABORATORY AND CLINICAL MEDICINE王凤泽; 沙丽; 乔玲;吴莲英; 张晓东; 叶丽虹. Promotion of transcriptional activity of NF-kappa B mediated by HBXIP in hepatoma cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS秦宵然; 张航; 周晓雷; 王长晔; 张惠中; 张晓东; 叶丽虹. Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. TRANSLATIONAL RESEARCH 张晓东; 张伟英; 叶丽虹. Pathogenesis of hepatitis B virus infection. FUTURE VIROLOGY 1-5-637-647. 2007-1-1乔玲; 徐治立; 谭旭; 叶丽虹;张晓东. Investigation of inhibition of Wnt/beta-catenin pathway in breast cancer cells mediated by Dkk-1 released from human mesenchymal stem cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS王凤泽; 沙丽; 张伟应;吴莲英; 乔玲; 李楠; 张晓东; 叶丽虹. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. ACTA PHARMACOLOGICA SINICA张晓东; 张航; 吴莲英; 沙丽; 刘树业; 邵新华; 叶丽虹. Anti-HBx in sera is a potential marker of development from hepatitis B (HB) to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21--A133-A133.叶丽虹; 蔡娜; 东楠; 李楠; 张伟英; 张航; 张烜; 吴莲英; 张晓东. Interference of RNA targeting hepatitis B virus x (HBx) gene reduces the tumorigenicity of hepatoma cells and HBx-transformed human liver cells. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21--A159-A159.张晓东; 蔡娜; 李楠; 张伟英;张航; 张烜; 吴莲英; 齐众; 叶丽虹. Transformation of human normal liver L-O2 cells induced by hepatitis B virus X protein, enhanced by highly expression level of survivin as a co-factor. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21--A179-A180.Zhang, XD; Zhang, H; Ye, LH. Effects of hepatitis B virus X protein on the development of liver cancer. JOURNAL OF LABORATORY AND CLINICAL MEDICINEZhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH, Zhang XD*. Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver c. J Biomed Biotechnol Zhang WY, Cai N, Ye LH, Zhang XD. Transformation of human liver L-O2 cells mediated by stable HBx transfection.. Acta Pharmacol Sinica.Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH, Zhang XD. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica SinicaYou J, Mi D, Zhou X, Qiao L, Xu S, Zhang X, Ye LH. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation . Endocrinology 1Zhou X, Liu Y, You J, Zhang X, Ye LH. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. . Cancer LettersQiao L, Xu ZL, Zhao TJ, Ye LH, Zhang XD. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters张学智, 山长亮, 叶丽虹,张晓东. RNA干扰在抗B肝治疗中的套用及其研究进展. . 生物化学与生物物理进展Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye L, Zhang X. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells.. Cell ResYe LH, Dong N ， Wang Q ， Xu ZL ， Cai N ， Wang HH ， Zhang X. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. IntervirologyZhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye L, Zhang X. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and it. Acta Pharmacologica Sinica Qiao L, Zhao T, Wang F, Shan C, Ye L, Zhang X. NF-κB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. . Acta Pharmacologica SinicaWang F, Sha L, Ye L*, Zhang X. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. . Acta Pharmacologica Sinica张烜，叶丽虹，张晓东. 骨桥蛋白通过NF-kB上调钙蛋白酶小亚基1促进肝癌细胞迁移. 生物化学与生物物理进展Cui WJ, Liu Y, Zhou XL, Wang FZ, Zhang XD, Ye LH. Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin.Zhang X, Ye LH, Zhang XD. A mutant of hepatitis B virus X protein (HBx?127) enhances cell migration via osteopontin (OPN) invo. Acta Pharmacol Sin.Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kap. J Med Virol. 82-5-920-928. 2010-5-1Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH, Zhang XD. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res.Wang Q, Zhang WY, Ye LH, Zhang XD. A mutant of HBx (HBxΔ127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin. Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye L, Zhang XD. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedba. Neoplasia.Zhou XL, Qin XR, Zhang XD, Ye LH. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/β-catenin signaling. Acta Pharmacol Sin.Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD, Ye LH. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3′. Cancer Biol Ther.张烜，叶丽虹，张晓东. B肝病毒X蛋白通过骨桥蛋白OPN促进肝癌细胞迁移. 中国生化与分子生物学学报周晓雷，张晓东, 叶丽虹. DKK-1通过上调nm23表达抑制乳腺癌细胞迁移。. 中国生化与分子生物学学报Wang Q, Zhang T, Ye LH*, Wang WH, Zhang XD.. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China. Cancer Epidemiology --Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*. MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK). Oncogene 2011--1-14. Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang XD*. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targetin. PLoS One 6-5-e19518. Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD*.. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin.张煊; 叶丽虹*; 张晓东*. Osteopontin(OPN) Upregulates Calpain Small Subunit 1(Capn4) via Nuclear Facter-kappa B in Promotion of Hepatoma Cell Migration. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS尤嘉琮，米达，周晓雷，乔玲，张航，张晓东* ，叶丽虹*. A Positive Feedback between Activated Extracellularly Regulated Kinase and Cyclooxygenase/Lipoxygenase Maintains Proliferation and Migration of Breast Cancer Cells. ENDOCRINOLOGY Zhang Xue-Zhi; Shan Chang-Liang; Ye Li-Hong; Zhang Xiao-Dong. Advantages of RNA interference in anti-hepatitis B virus therapy. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS Nan HU, Yu LI, Yu ZHAO, Qi WANG, Jia-cong YOU, Xiao-dong ZHANG, Li-hong YE. A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. ACTA PHARMACOLOGICA SINICA?? Changliang Shan, Shuai Zhang, Wenjing Cui, Xiaona You, Guangyao Kong, Yumei Du, Liyan Qiu, Lihong Yeand Xiaodong Zhang. Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cells from complement attack. Carcinogenesis Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang W, Zhang X, Ye L.. miR-520b Regulates Migration of Breast Cancer Cells by Targeting Hepatitis B X-interacting Protein and Interleukin-8. J Biol Chem张涛, 张俊萍, 由晓娜, 刘迁, 杜玉梅, 高玉恩, 山长亮, 孔光耀, 叶丽虹，张晓东. Hepatitis B Virus X Protein (HBx) Modulates Oncogene YAP via CREB to Promote Growth of Hepatoma Cells. . Hepatology 杜玉梅, 孔光耀由晓娜, 张帅，张涛, 叶丽虹, 张晓东. Up-regulated long non-coding RNA HULC by HBx enhances growth of hepatoma cells via down-regulating p18.. J Biol Chem. --.Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH, Zhang XD. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving . PLoS One 2012;7Zhang W, Kong G, Zhang J, Wang T, Ye LH, Zhang XD. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2): e3Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD, Ye LH. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells . FEBS LettersZhao Y, Wang W, Wang Q, Zhang XD, Ye LH. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor. Biochem Biophys Res Commun. Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang HK, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N, Chen MS, Du YM, Xia JC, Ye LH*, Zhang XD*. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/Alu core sequence/subtelomeric DNA. FEBS Letters Liu SP, Li LL, Zhang YY, Zhang YW, Zhao Y, Lin ZH, Zhang XD*, Ye LH*. HBXIP upregulates s100a4 via stat4 and pten to promote growth and migration of breast cancer cells. J Biol Chem