双面胶成分,双面胶成分怎么写( 二 ) _百科达人

小鼠心脏粘接
人体双面胶的可能应用
赵选贺团队进一步展示了人体双面胶的多种可能应用。人体双面胶能协助外科医生完成切口密封以及帮助伤口愈合。特别地，和手术缝合线相比，人体双面胶针对相对柔软、脆弱的肺及气管等器官表现出明显优势，且能够规避手术缝合不完善造成的胃肠泄漏问题。其次，由于人体双面胶适用于组织之外的多种材料，可用于向人体植入多种医疗器件，包括心脏等器官的修复器件、健康监控设备、药物缓释载体等。和传统的缝合手段相比，人体双面胶易于操作、有效避免伤害器官并导致并发症的风险。
不同应用场景
模型指导设计人体双面胶
赵选贺团队的毛新宇同学开发了人体双面胶吸水的物理模型。根据不同组织器官的含水量，可以预测双面胶的吸水量和吸水时间。该模型指导赵选贺团队，针对不同组织器官，设计不同性能和厚度的双面胶，保证5秒钟内干燥潮湿表面，实现快速坚韧粘结。
大家点评
哈佛医学院的组织工程学和生物3D打印专家Shrike Zhang教授评教此工作：
“This is an excellent innovation by Professor Zhao's team, which essentially lies in a very simple yet extremely effective concept of double-sided tissue adhesive. It fundamentally deviates from how bioadhesives are traditionally designed and implemented -- instead of starting wet, this double-sided tape begins dry and thin. Intriguingly, such fundamental deviation lands beautifully on a fundamental improvement as well -- as soon as the tape is applied at the target wound site, the wetting process that simultaneously removes water molecules from the tissue surface induces almost instantaneous strong physical bonding, which overtime, transitions into stable chemicalbonding through the built-in reactive groups as the swelling of the tape continues to develop into a piece of biocompatible, biodegradable, water-rich hydrogel. The formed hydrogel, due to its double-network nature, stays mechanically robust leading to perfect sealing of the wound until it heals. I pleasantly anticipate tremendous translational potential of this elegant approach into various clinical practices as well as basic engineering applications, in particular in situations where surgical operations, such as suturing, are not straightforward.”
法国 ESPCI的主任、粘合学专家Costantino Creton评价人体双面胶：
“Combining two innovative concepts, the research team succeeded in adhering quickly and effectively to the wet and soft surface of a tissue, and in maintaining good adhesion and mechanical properties for several days without causing too much inflammatory response.”
作者展望
人体双面胶基于新型的干燥交联机理，能够迅速并强力地粘合多种体内组织及医疗器械，长期保持高粘接强度、高柔韧性、高生物兼容性，最终生物降解。因此和传统的生物胶水相比具有巨大的潜力，是一种替代手术缝合线的潜在手段。人体双面胶具有优异的粘接性能、柔性、生物相容性、可降解性以及长久储存的能力。除此之外，人体双面胶在生物支架、药物缓释、可穿戴及可植入医疗器件领域提供了新的机遇。人体双面胶的干燥交联机理同时为发展下一代可用于潮湿环境及水下的新型粘接材料指出了新的方向。
团队介绍
该工作由MIT赵选贺团队主导完成。通讯作者赵选贺博士是MIT终身教授。该工作的第一作者是赵选贺团队的博士生Hyunwoo Yuk及MIT博士生Claudia E. Varela 。其他作者包括Christoph S. Nabzdyk、Xinyu Mao、Robert F. Padera和Ellen T. Roche等。
MIT赵选贺团队（http://zhao.mit.edu）专注推动软材料和人机共融科技，最近的成果包括：
机理研究
首次提出干燥交联（dry-crosslinking）机理,用于粘合各种潮湿表面（wet adhesion）。发明人体双面胶（tissue double-sided tape），能够在5秒内粘合软湿组织器官和植入设备，并保持长期坚韧、柔软且生物兼容。Nature (2019)首次提出水凝胶超韧粘结（tough adhesion）的机理并实现与各种材料的超韧粘结 Nature Materials, 15, 190 (2016)首次提出3D打印铁磁软材料和软机器 Nature, 558, 274 (2018)首次提出坚韧水凝胶高弹体聚合物（tough hydrogel-elastomer hybrid）并实现不干水凝胶 (anti-dehydration hydrogel) Nature Communications, 7, 12028 (2016)首次实现超高抗疲劳断裂（anti-fatigue-fracture）水凝胶 Science Advances, 5: eaau8528 (2019)；PNAS,116 (21) 10244-10249 (2019)首次提出3D打印超韧超弹水凝胶的方法并打印各种载细胞的超韧超弹水凝胶结构 Advance Materials, 27, 4035 (2015)首次提出可重复折叠大面积石墨烯 Nature Materials, 12, 321 (2013)首次发现并解释电致褶皱（electro-creasing）和电致空穴（electro-cavitation）现象 Physical Review Letters, 106, 118301 (2011)； Nature Communications, 3, 1157 (2012).应用研究